South America has a lot of variety from the traveler perspective, but one of the most adventurous and exotic experiences is the crossing of the Chilean and Bolivian Altiplano to the Uyuni Salt flats and later Titicaca Lake.
The trip normally starts in Santiago de Chile with an exposure to delicious Chilean wines and sea food. From there the adventure takes you to the driest desert on Earth, the Atacama. This inhospitable place offers the opportunity to acclimatize to what later will be a crossing following dirt roads in altitudes of 11500 ft.